Alternatively activated macrophages and fibrosis lung

We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 as the most powerful inducer of M2-phenotype in AM and monocytes.

Macrophages in Lung Injury, Repair, and Fibrosis
Macrophages in Lung Injury, Repair, and Fibrosis

We found elevated spontaneous production of the chemokines CCL17, CCL18 and CCL22 and increased expression of CD206 by alveolar macrophages from patients with lung fibrosis. Stimulation of normal human AM with Th2 cytokines IL-4 and/or IL-10 in vitro revealed IL-4 as the most powerful inducer of M2-phenotype in AM and monocytes.

Alternatively activated alveolar macrophages in …

Alternatively activated alveolar macrophages in …

18-02-2021

Macrophages in Lung Injury, Repair, and Fibrosis

Macrophages in Lung Injury, Repair, and Fibrosis

 · The classically activated macrophage (M1) and alternatively activated macrophage (M2) have been extensively investigated in lung injury, repair, and fibrosis. In the present review, we summarized the current data on monocyte-derived macrophages that are recruited to the lung, as well as alveolar resident macrophages and their polarization, pyroptosis, and phagocytosis in acute lung …

Afbeeldingen van Alternatively Activated Macrophages and fibrosi…

Afbeeldingen van Alternatively Activated Macrophages and fibrosi…

01-10-2010

http://video-japan-helen-hall-qgr.duckdns.org

Alternatively activated alveolar macrophages in …

Alternatively activated alveolar macrophages in …

 · These results indicate that alternatively activated macrophages in the airways of patients suffering from fibrotic lung diseases not only display a specific pattern of marker expression but also have adopted particular characteristics with regard to their responsiveness towards Th2 cytokines throughout the development of disease.

http://video-japan-mary-parker-yxk.duckdns.org

Ly6Chi monocytes direct alternatively activated ...

Ly6Chi monocytes direct alternatively activated ...

Conclusions: We demonstrate the importance of circulating monocytes and lung macrophages during pulmonary fibrosis, and emphasize the importance of the alternatively activated macrophage phenotype. We show that Ly6Chi monocytes facilitate the progression of pulmonary fibrosis, but are not obviously engrafted into lungs thereafter.

http://video-japan-sandra-collins-sby.duckdns.org

IL-33 promotes ST2-dependent lung fibrosis by the ...

IL-33 promotes ST2-dependent lung fibrosis by the ...

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice J Allergy Clin Immunol . 2014 Dec;134(6):1422-1432.e11. doi: 10.1016/j.jaci.2014.05.011.

http://video-japan-nancy-parker-wyc.duckdns.org

S100a4 Is Secreted by Alternatively Activated …

S100a4 Is Secreted by Alternatively Activated …

Finally, we inhibit S100a4 in vivo in the bleomycin-induced lung fibrosis model by treatment with niclosamide. Our data suggest that S100a4 is produced and secreted by M2 polarized alveolar macrophages and enhances the proliferation and activation of lung fibroblasts.

http://video-japan-maria-parker-rhf.duckdns.org

Macrophages in Lung Injury, Repair, and Fibrosis

Macrophages in Lung Injury, Repair, and Fibrosis

The classically activated macrophage (M1) and alternatively activated macrophage (M2) have been extensively investigated in lung injury, repair, and fibrosis. In the present review, we summarized the current data on monocyte-derived macrophages that are recruited to the lung, as well as alveolar resident macrophages and their polarization, pyroptosis, and phagocytosis in acute lung injury (ALI).

http://video-japan-carol-walker-jzy.duckdns.org

Mechanisms of the alternative activation of macrophages ...

Mechanisms of the alternative activation of macrophages ...

alternatively activated M2 macrophages and discuss the involvement of ncRNAs in RILF development and progression. MACROPHAGES PROMOTE LUNG FIBROSIS Lung fibrosis is caused by repetitive injury to the epithelial cells lining the alveoli, resulting in scarring of the lung …

http://video-japan-michelle-clark-tdp.duckdns.org

Dectin-1 Is a Marker of Alternatively Activated ...

Dectin-1 Is a Marker of Alternatively Activated Macrophages and a Therapeutic Target in Interstitial Fibrotic Lung Diseases

HIF1A up-regulates the ADORA2B receptor on …

Additionally, alternatively activated macrophages (AAMs) expressing ADO … Idiopathic pulmonary fibrosis (IPF) is a deadly chronic lung disease. Extracellular accumulation of adenosine and subsequent activation of the ADORA2B receptor play important roles in regulating inflammation and fibrosis in IPF.

Генераторы Дорвеев