Hypoxia activated prodrugs review of literature

31-12-2020

Hypoxia Activated Prodrugs: Factors Influencing …

31-12-2020

Hypoxia‐Activated Prodrugs of PERK Inhibitors - …

 · Hypoxia Activated Prodrugs: Factors Influencing Design and Development. ... In this review, ... we will utilize select examples from the literature to reinforce these factors, and make a case for the intelligent design of new HAPs, leading to the development of novel hypoxia targeting chemotherapeutic agents. PMID:

Molecular Pathways: Hypoxia-Activated Prodrugs …

Hypoxia presents a target for tumour‐selective drug delivery using hypoxia‐activated prodrugs. We designed and prepared hypoxia‐activated prodrugs of modified PERK inhibitors using a 2‐nitroimidazole bioreductive trigger. The new inhibitors retained PERK kinase inhibitory activity and the corresponding prodrugs were strongly deactivated.

Hypoxia Activated Prodrugs: Factors Influencing …

This review discusses the development of the hypoxia-activated prodrugs and their applicability in treating both hematologic malignancies and solid tumors. Clin Cancer Res; 23(10); 2382-90. …

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Hypoxia Activated Prodrugs: Factors Influencing …

NitroCBIs are thus examples of hypoxia-activated prodrugs (HAPs), compounds designed to take advantage of the low oxygen concentrations commonly found …

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Hypoxia Activated Prodrugs: Factors Influencing …

In this review, we will describe the ... Hypoxia Activated Prodrugs: Factors Influencing Design and Development. VOLUME: ... we will utilize select examples from the literature to reinforce these factors, and make a case for the intelligent design of new HAPs, leading to the development of novel hypoxia targeting chemotherapeutic agents.

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Combining hypoxia-activated prodrugs and …

Hypoxia Activated Prodrugs: Factors Influencing Design and Development Buy Article: $68.00 + tax ... In this review, ... we will utilize select examples from the literature to reinforce these factors, and make a case for the intelligent design of new HAPs, leading to the development of novel hypoxia targeting chemotherapeutic agents. No References.

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In silico analysis of hypoxia activated prodrugs in ...

03-08-2020

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A Novel Model System for Understanding …

 · Hypoxia-activated prodrugs are drugs that act as Trojan horses, they are theoretically harmless vehicles that are converted into warheads when they reach their targets: hypoxic tumour regions. Despite being conceptually clever and successful in experimental settings, hypoxia-activated prodrugs are yet to achieve successful results in clinical trials.

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Investigational Hypoxia-Activated Prodrugs: …

28-05-2020

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 · Hypoxia-activated prodrugs (HAPs) have emerged as a method for selective targeting of tumours through the exploitation of their hypoxic cores. HAPs are bioreductive compounds which remain inactive under normoxic conditions, but are metabolized under hypoxic conditions within the body into their cytotoxic forms.

Reports on the comprehensive factors for design considerations of hypoxia-activated prodrugs (HAPs) are rare. We introduced a new model system composed of a series of highly water-soluble HAPs, providing a platform to comprehensively understand the interaction between HAPs and hypoxic biosystems. Specifically, four kinds of new HAPs were designed and synthesized, containing the same ...

Hypoxia-activated prodrugs (HAPs) can be selectively activated by reductase under hypoxia. Some promising HAPs have been already achieved, and many clinical trials of HAPs in different types of cancer are ongoing. However, none of them has been approved in clinic to …

Генераторы Дорвеев